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. Author manuscript; available in PMC: 2010 Aug 4.
Published in final edited form as: J Neuroimmunol. 2007 May 18;187(1-2):55–60. doi: 10.1016/j.jneuroim.2007.04.011

Fig. 1.

Fig. 1

Central administration of IGF-I abrogates the reduction in social exploration caused by central TNFα in both WT and TNF-R2−/− mice. Mice were pretreated i.c.v. with either aCSF or IGF-I (300 ng/1 μl/mouse) and then injected centrally with either aCSF or TNFα (50 ng/1 μl/mouse). Duration of social exploration was measured at 0, 2, 6 and 24 h post-treatment in WT (A) and TNF-R2−/− (B) mice. Each value represents the mean ± SEM (n=6/group; * p<0.01 compared to aCSF + aCSF and# comparing IGF-I + TNFα to aCSF + TNFα).