Table 1.

IGF-I reverses the loss of body weight induced by injections of central TNFα.

Strain	Treatment	Change in Body Weight (g)
WT	aCSF + aCSF	1.35 ± 0.23
	aCSF + TNFα	−1.49 ± 0.41*
	IGF-I + aCSF	0.96 ± 0.35
	IGF-I + TNFα	2.27 ± 0.51#
TNF-R2−/−	aCSF + aCSF	0.75 ± 0.32
	aCSF + TNFα	−1.53 ± 0.21*
	IGF-I + aCSF	0.36 ± 0.10
	IGF-I + TNFα	0.33 ± 0.07#

Body weight changes were determined for WT (top) and TNF-R2-deficient (bottom) mice from weights obtained before and 24 h after i.c.v. treatment. Each value represents the mean ± SEM

n=6/group

^*p<0.001 compared to the aCSF + aCSF treatment within strain

^#p<0.001 compared to the aCSF + TNFα treatment within strain.