Table 1. Attenuation of AGS in APP/Aβ-Overexpressing Mice.
| GenotypeXO | n | Treatment | % WR | % AGS | % death |
|---|---|---|---|---|---|
| WT | 39 | untreated | 8 | 5 | 5 |
| Tg2576 | 16 | untreated | 56* | 38* | 38* |
| FRA×AD | 24 | untreated | 88* | 79* | 58* |
| Cn | 13 | untreated | 31 | 15 | 15 |
| Ts65Dn | 16 | untreated | 75ˆ | 56ˆ | 50 |
| WT | 19 | MPEP | 0 | 0 | 0 |
| Tg2576 | 15 | MPEP | 0# | 0# | 0# |
| FRA×AD | 15 | MPEP | 60# | 27# | 7# |
| WT | 26 | Fenobam | 4 | 4 | 4 |
| Tg2576 | 27 | Fenobam | 30 | 15 | 0# |
| Cn | 11 | Fenobam | 0# | 0 | 0 |
| Ts65Dn | 12 | Fenobam | 58 | 0# | 0# |
| WT | 18 | αAβ | 6 | 0 | 0 |
| Tg2576 | 13 | αAβ | 8# | 8 | 0# |
X
WT, Tg2576 and FRA×AD are in a C57BL/6 background
O
Ts65Dn and control littermates (Cn) are in a mixed background
*
statistically different from untreated WT, p<0.005
ˆ
statistically different from Cn p<0.03
#
statistically different from untreated of same genotype, p<0.05