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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: J Immunol. 2010 Mar 15;184(8):4497–4509. doi: 10.4049/jimmunol.0903131

FIGURE 5.

FIGURE 5

Requirements for IKKβ, IKKα, and p52 for cellular velocity in the initial phase of HMGB1-induced cell migration. A–C, All cell tracks of WT MEFs versus their IKKβ, IKKα, and p52 null counterparts in Fig. 4 were analyzed for velocities 30 and 60 min after exposure to their respective HMGB1 gradients. Velocity is the total path traveled divided by the time of observation. WT refers to either primary IKKαf/f:CreERT2 or IKKβf/f:CreERT1 MEFs. IKKα−/− and IKKβ−/− MEFs were generated from the latter respective WT cells by exposure to 4-OHT for 36 h. Bars are mean velocities, and error bars are SEs of the mean.*p = 0.009; **p = 0.003; ***p < 0.0001. Experiments were repeated two to four times with comparable results.