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. Author manuscript; available in PMC: 2011 Apr 15.
Published in final edited form as: J Immunol. 2010 Mar 15;184(8):4497–4509. doi: 10.4049/jimmunol.0903131

FIGURE 6.

FIGURE 6

IKKβ, but not IKKα, is required to induce RAGE mRNA expression in MEFs in response to HMGB1. A and B, Real-time RT-PCR analysis of RAGE mRNA expression in WT versus IKKβ−/− and IKKα−/− MEFs in response to HMGB1 (50 ng/ml) for 3 h. Primary WT IKKβf/f CreERT1 MEFs were pre-exposed to 4-OHT to delete IKKβ in A, and immortalized WT and IKKα−/− MEFs were used in B. Experiments were performed three times each in duplicate. *p = 0.04.