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. Author manuscript; available in PMC: 2010 Aug 4.
Published in final edited form as: Eur J Neurosci. 2009 Apr;29(8):1588–1603. doi: 10.1111/j.1460-9568.2009.06706.x

Figure 2. Nicotine increases the frequency of sIPSCs in pyramidal cells via activation of non-α7 nAChRs.

Figure 2

(A) Bath application of nicotine (20 μM) in the presence of DNQX (20 μM) and AP5 (40 μM) reversibly increased the frequency of sIPSCs in pyramidal cells voltage-clamped at −70 mV. (B) Preapplication of TTX (0.2-0.5 μM) blocked the effect of nicotine. (C) The non-α7 nAChR agonist A85380 (1 μM) mimicked the effect of nicotine. (D) The α7 nAChR agonist choline (1 mM) had no significant effect on the frequency of sIPSCs. (E) Summary plot of the effects of different nicotinic agonists and antagonists on the frequency of sIPSCs as a percentage of control. *P < 0.05, **P < 0.01, ***P < 0.001.