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. Author manuscript; available in PMC: 2010 Aug 4.
Published in final edited form as: J Neurochem. 2009 Jun 15;110(4):1254–1262. doi: 10.1111/j.1471-4159.2009.06222.x

Figure 2.

Figure 2

TGF-β1 contains putative lipid binding domains. A, Schematic representation of lipid-binding amphipathic α-helices in pro-TGF-β1, identified by COMBO, COMMET, and CONSENSUS. Type G* or Y amphipathic helices (blue, and grey) are drawn to scale. Type G* amphipathic helices in mature TGF-β (blue, green and yellow) correspond to the same colored regions in B. B, Lipid-binding regions (blue, green and yellow) present in mature TGF-β1 form two putative lipid-binding domains. The blue region of the first chain forms a hydrophobic patch together with the green region of the second chain as shown. Grey and nude colors represent individual TGF-β1 peptides. Numbers shown correspond to amino acid numbering of pro-TGF-β.