Table 9.
Survival-related single factors, tendencies of correlation
| Factor | Relation to survival, clear tendency | Significant (only) in bivariate correlation with survival (two-tailed), level |
|---|---|---|
| IHC markers, semiquantitatively, when increasing number of cells with positive IR: | ||
| Calretinin, nucleus | ↑ | - |
| Calretinin, cytoplasm | ↔ | - |
| EMA, cell membrane | ↔ | - |
| EMA, cytoplasm | ↔ | - |
| Podoplanin, cell membrane | ↑ | 0.001 |
| Mesothelin, cell membrane | if 0-50%: ↓ 51-100%: ↑ |
- |
| Ber-Ep4, general | if 1-25%: (↓) | - |
| Histological type | ||
| Epithelial | ↑ | 0.05 (non-parametric) |
| Mixed | ↓ | 0.01 (non-parametric) |
| Histological markers | ||
| a) when increasing: | ||
| Degree of cellular atypia | ↓ | 0.001 |
| Spindle cells, semiquantitatively | if 0: ↑; otherwise: ↓ | 0.001 (non-parametric) |
| Number of mitoses (10 HPF) | if 0 or 1: ↑; otherwise:↓ | 0.05 (Spearman's rho) |
| Number of atypical mitoses (10 HPF) | if 0: ↑; otherwise: ↓ | - |
| Necrosis | ↓ | 0.01 |
| Mucus, cytoplasm, number of cells | if high: (↓) | - |
| Mucus, extracellular, number of cells | ↔ | - |
| Accompanying inflammation, intensity | ↔ | - |
| Accompanying inflammation, focality | ↔ | - |
| b) if present: | ||
| MM spreading, perineural | (↔) | - |
| MM spreading, intralymphangic | (↔) | - |
| MM spreading, intralymphangic and venoles | (↓) | - |
| No/no evident MM spreading | ↑ | - |
| Accompanying inflammation, active | (↔) | - |
| Accompanying inflammation, non-active | ↔ | - |
| Localisation of primary tumour | ||
| Pleura | ↓ | - |
| Peritoneum | ↑ | 0.01 (parametric) 0.05 (non-parametric) |
| Pleura and peritoneum | (↓) | - |
| Mediastinum, not specified | (↓) | - |
| Pericardium | (↓) | - |
| Scrotum | (↓) | - |
| Metastasis | 0.05 (non-parametric) | |
| yes | ↓ | |
| no/not known | ↑ | |
| Sex | - | |
| Female | ↔ | - |
| Male | ↔ | - |
| Age at time of diagnosis, when increasing: | ↓ | 0.01 |
In parentheses: very few cases
Survival is given per April 21, 2008.