Table 2.
Adjustment for Differences in Patient Characteristics between Study Arms: Sensitivity to Prior Distributions
Type of Prior | ||||
---|---|---|---|---|
Dataset | Posterior Estimate Median OR (95% credible interval) |
Base Case Analysis: " Reasonably Vague" (Grines) |
Sensitivity Analysis: "Fairly Unrestrictive" (Prevost) |
Sensitivity Analysis: " Vaguest" |
Overall (μ) | 0.37 (0.17,0.77) | 0.37 (0.23,0.60) | 0.37 (0.18,1.25) | |
Base Case 3 Covariatesa (k = 44) |
Randomised (θ1) | 0.35 (0.17,0.63) | 0.36 (0.21,0.59) | 0.34 (0.13,0.74) |
Non-Randomised (θ2) | 0.39 (0.25,0.61) | 0.38 (0.25,0.57) | 0.40 (0.23,0.68) | |
Overall (μ) | 0.45 (0.20,0.95) | 0.47 (0.28,0.74) | 0.44 (0.13,1.31) | |
Imputed 5 Covariatesb (k = 79) |
Randomised (θ1) | 0.42 (0.18,0.78) | 0.46 (0.25,0.73) | 0.39 (0.14,0.87) |
Non-Randomised (θ2) | 0.49 (0.33,0.72) | 0.49 (0.33,0.71) | 0.49 (0.32,0.74) |
a.male, age, cardiac disease, b.male, age, cardiac disease, pulmonary disease, renal disease