Fig. 7.

Ca²⁺ _i transients (Indo-1 ratio_405/495 nm, systolic–diastolic) in field-stimulated cardiomyocytes at baseline and during superfusion with either Ang II or ISO. The stimulatory effects of Ang II were abolished in myocytes with genetic (TRPC3^−/−/C6^−/−) (a) or pharmacological inhibition of TRPC channels (2 μM BTP 2, pretreatment during 15 min) (c). The effects of ISO were preserved (b, d). Asterisks denote a significant difference versus basal (B) (P < 0.05). For each condition, six cells from four mice were tested