A) Mean (±SEM) number of infusions for rats trained to self-administer 0.025, 0.05 and 0.1 mg/kg/infusion methamphetamine (ns= 7, 8, and 9, respectively) during acute testing with vehicle, 10, 30, and 60 mg/kg bupropion. Bupropion (30 and 60 mg/kg) decreased methamphetamine infusions. B) Mean (±SEM) responses on the inactive lever during acute testing. C) This graph illustrates the mean (±SEM) activity during the self-administration sessions. *Significant difference from vehicle and 10.