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Proposed model. In embryonic stem (ES) cells, Hes1 expression is controlled by LIF and BMP. Hes1 suppresses Notch signaling by repressing Dll1 and Jag1 expression and thereby inhibiting neural differentiation. Sustained Hes1 expression leads ES cells to the mesodermal differentiation but inhibits the following commitment probably at the mesodermal stem/progenitor state.
