Skip to main content
. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Hypertension. 2010 May 3;55(6):1461–1467. doi: 10.1161/HYPERTENSIONAHA.110.150029

Figure 4. Schematic pathway of CYP1B1 dependent Ang II-induced migration, proliferation and hypertrophy of VSMCs.

Figure 4

ROS generated via CYP1B1 from AA released consequent to activation of cPLA2, stimulate one or more signaling molecules (ERK 1/2 and p38MAPK) that in turn mediates the action of Ang II on VSMC migration and DNA and protein syntheses in VSMCs.