TABLE 1.

S. Typhi proteins bound by acute- and convalescent-phase serum antibody fractions from bacteremic patients and identified by mass spectrometric analysis^a

Protein group and Swiss-Prot ID	Protein name(s)	Gene locus	Protein description	IgG		IgA		IgM
				A	C	A	C	A	C
Cellular processes, virulence, and pathogenesis
Q8Z7B8		STY1364	Hypothetical periplasmic protein	X	X
Q8Z727	HlyE	STY1498	Hemolysin E	X	X			X	X
Q8Z6B2	PagC	STY1878	Outer membrane invasion protein	X	X
Q8Z6A7	CdtB	STY1886	Cytolethal distending toxin subunit B homolog	X	X
Q8Z6A4	PltA	STY1890	Putative pertussis-like toxin subunit	X	X
Cell envelope
Q8Z939		STY0351	Possible outer membrane adhesion	X	X
Q8XH17	OmpX	STY0872	Outer membrane protein X	X	X
Q8Z7S0	OmpA	STY1091	Outer membrane protein A	X	X
Q8Z5I6	RfbH	STY2300	Putative dehydratase RfbH	X				X
P67913	HldD	STY4085	ADP-l-glycero-d-manno-heptose-6-epimerase					X
Amino acid biosynthesis
Q8Z9A8	DapD	STY0236	2,3,4,5-Tetrahydropyridine-2,6-dicarboxylate	X				X
Q8Z7N9	WrbA	STY1155	Flavoprotein WrbA	X		X		X
Q8Z3B6	MetE	STY3594	5-Methyltetrahydropteroyltriglutamate-homocysteine					X
Q8Z381	IlvC	STY3648	Ketol acid reductoisomerase	X				X
Q8Z123	ArgI	STY4807	Ornithine carbamoyltransferase	X				X
Biosynthesis of cofactors, prosthetic groups, and carriers
P66039	RibH	STY0456	6,7-Dimethyl-8-ribityllumazine synthase					X
P0A2E2	GlyA	STY2802	Serine hydroxymethyltransferase	X	X			X	X
Central intermediary metabolism
Q8Z3Q5		STY3330	Possible oxidoreductase	X				X
Q934J6	PhoN	STY4519	Nonspecific acid phosphatase		X
P65749	Ppa	STY4773	Inorganic pyrophosphatase	X	X
Energy metabolism
Q8Z9F0	AceE	STY0175	Pyruvate dehydrogenase E1 component					X
Q8Z9E9	AceF	STY0176	Dihydrolipoamide acetyltransferase component		X
Q8Z9E8	LpdA	STY0177	Dihydrolipoamide dehydrogenase					X
P66870	SucC	STY0781	Succinyl-CoA ligase					X
Q8XF12	TrxB	STY0956	Thioredoxin reductase	X				X	X
Q8XGV7	PflB	STY0973	Formate acetyltransferase 1					X	X
Q8Z7F1	Adh	STY1302	Alcohol dehydrogenase					X
Q8Z747	YdcW	STY1467	Gamma-aminobutyraldehyde dehydrogenase					X
P0A1P1	GapA	STY1825	Glyceraldehyde 3-phosphate dehydrogenase	X				X
Q8Z5J3	Gnd	STY2290	6-Phosphogluconate dehydrogenase, decarboxylating	X				X
Q8Z4T0	TalA	STY2710	Transaldolase A					X
P64077	Eno	STY3081	Enolase	X	X
Q8XFG7	Fba	STY3226	Fructose 1,6-bisphosphate aldolase	X	X			X
P65703	Pgk	STY3227	Phosphoglycerate kinase	X	X			X
P65693	PrkA	STY3809	6-Phosphofructokinase					X
Q8Z2D5	AldB	STY4116	Aldehyde dehydrogenase B					X
Q8Z1T0	Qor	STY4441	Quinone oxidoreductase					X
Q8XFR3	AspA	STY4685	Aspartate ammonia-lyase					X
Q8Z0U3	DeoC	STY4918	Deoxyribose-phosphate aldolase	X
Fatty acid and phospholipid metabolism
Q8Z7C7	FabI	STY1352	Enoyl-(acyl carrier protein) reductase (NADH)					X
Protein fate
Q8Z9R1	DnaK	STY0012	Chaperone protein DnaK					X
Q8Z934	PepD	STY0361	Aminoacyl-histidine dipeptidase	X				X
Q7AMH5	ClpB	STY2849	Chaperone protein ClpB					X
P0A1D4	GroEL	STY4690	60-kDa chaperonin	X	X			X
Protein synthesis
P67564	SerS	STY0961	Seryl-tRNA synthetase					X
Q8XGK9	RpsA	STY0981	30S ribosomal protein S1					X
Q56112	AsnS	STY1004	Asparaginyl-tRNA synthetase					X
Q8Z5W1	AspS	STY2109	Aspartyl-tRNA synthetase					X
P0A1H4	FusA	STY4352	Elongation factor G					X
Q8Z118	ValS	STY4814	Valyl-tRNA synthetase					X
P0A1H6	TufA, TufB	STY4353 STY3739	Elongation factor Tu	X	X	X		X
Biosynthesis of purines, pyrimidines, nucleosides, and nucleotides
Q8Z4Q3	GuaA	STY2751	GMP synthase					X
Regulatory function
Q8Z3E9	SspA	STY3523	Stringent starvation protein A					X
Transcription
Q8Z320	RpoB	STY3732	DNA-directed RNA polymerase subunit beta					X
P0A7Z8	RpoA	STY4383	DNA-directed RNA polymerase subunit alpha					X
Transport and binding
Q8Z1Y0	Bfr	STY4355	Bacterioferritin	X	X
Unclassified
Q8Z5C3	MetG	STY2384	Methionyl-tRNA synthetase					X

^aID, identifier; A, bound by immunoglobulin in acute-phase samples; C, bound by immunoglobulin in convalescent-phase samples; X, presence; CoA, coenzyme A.