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Proposed model of gene regulation by pknB. In USA300, pknB acts as an activator of both atl and sigB. Its actions upon sigB are predicted to make the cell more resistant to harsh environmental conditions and less virulent based on the role of sigB in cell stress and its actions upon sarA and agr. In addition to reduced virulence, the decreased expression of the downstream effector splF in the pknB+ strain is predicted to reduce the degradation of the Atl proenzyme.
