TABLE 2.

Effect of pknB on the susceptibility of Staphylococcus aureus strain USA300 to β-lactam antibiotics^a

Antibiotic	MIC for USA300
	Wild type	pknB	pknB/pEPSA5	pknB/pknB+
Oxacillin	32	1	0.5	8
Cloxacillin	1	0.125	0.25	2
Penicillin	16	0.25	0.25	16
Carbenicillin	64	1	2	16
Nafcillin	32	1	0.5	16
Ceftriaxone	64	8	8	16
Cephalothin	32	1	0.5	16
Cefazolin	32	0.5	0.5	32
Imipenem	22	37	40	27

^aAll MICs, with the exception of those for imipenem, are presented in μg/ml. Imipenem sensitivity was measured as zones of clearing in mm.