TABLE 3.
Main genes affected by LuxS and AI-2
| Gene function and identifier | Gene product | Log2 ratio |
|
|---|---|---|---|
| Mutant/WT | Mutant + AI-2/WT | ||
| Metabolism genes | |||
| SAOUHSC_00898 | Argininosuccinate lyase | −0.7 | −0.6 |
| SAOUHSC_01540 | Prophage L54a, HNH endonuclease family protein | −1 | −0.1 |
| SAOUHSC_00311 | Ascorbate-specific PTSa enzyme IIB | 1 | 2.5 |
| SAOUHSC_01532 | SLT open reading frame 110-like protein | 0.8 | −0.1 |
| SAOUHSC_01536 | Scaffolding protease | 1 | 0.4 |
| SAOUHSC_02311 | Potassium-translocating P-type ATPase, B subunit, putative | 1.2 | 0.8 |
| SAOUHSC_02374 | HmrA, aminobenzoyl-glutamate utilization protein B, putative | 2 | 1.9 |
| SAOUHSC_02468 | Acetolactate synthase | 0.8 | 0 |
| SAOUHSC_00310 | Ascorbate-specific PTS enzyme IIC | 2.5 | 2.7 |
| SAOUHSC_00312 | PTS IIA component | 2.6 | 2.8 |
| SAOUHSC_02933 | Betaine aldehyde dehydrogenase | 0.9 | 0.5 |
| SAOUHSC_02173 | Amidase, lytic enzyme | 1.5 | 1.3 |
| Membrane component genes | |||
| SAOUHSC_00062 | Integral membrane domain-containing protein | −0.9 | −0.3 |
| SAOUHSC_02821 | Membrane-spanning protein, putative | −0.7 | −0.6 |
| SAOUHSC_01386 | Phosphate ABC transporter, permease protein, putative | −0.9 | −0.1 |
| SAOUHSC_01084 | Cell wall surface anchor protein | −0.7 | −0.2 |
| SAOUHSC_02310 | KdpC, potassium-transporting ATPase, C subunit | 0.9 | 0.6 |
| SAOUHSC_02312 | KdpA, potassium-transporting ATPase, A subunit | 1.4 | 0.8 |
| SAOUHSC_02864 | Ferrous iron transport protein B | 0.8 | 0.6 |
| Regulator genes | |||
| SAOUHSC_00915 | Sua5/YciO/YrdC/YwlC family protein | −0.9 | 0.2 |
| SAOUHSC_03046 | Helix-turn-helix domain-containing protein | −0.7 | −0.4 |
| SAOUHSC_03046 | Helix-turn-helix domain-containing protein | −0.7 | −0.4 |
| SAOUHSC_03046 | Helix-turn-helix domain-containing protein | −0.7 | −0.4 |
| Virulence genes | |||
| SAOUHSC_00399 | Superantigen-like protein | −1 | 0.1 |
| SAOUHSC_00433 | Pathogenicity island protein | −0.8 | −1.3 |
| SAOUHSC_00384 | Superantigen-like protein | −0.9 | −0.7 |
| SAOUHSC_00389 | Superantigen-like protein | −0.9 | −1.1 |
| SAOUHSC_00121 | CapH | 0.9 | 0.7 |
| SAOUHSC_00122 | CapI | 1.0 | 0.8 |
| SAOUHSC_00123 | CapJ | 0.8 | 0.8 |
| SAOUHSC_00124 | CapK | 1 | 0.9 |
| SAOUHSC_00119 | CapF | 1 | 0.7 |
| SAOUHSC_00120 | CapG | 1 | 0.6 |
| SAOUHSC_00125 | CapL | 0.8 | 0.8 |
| SAOUHSC_00126 | CapM | 0.9 | 0.9 |
| SAOUHSC_00127 | CapN | 1 | 0.6 |
| SAOUHSC_00117 | CapD | 0.7 | 0.3 |
| SAOUHSC_00118 | CapE | 0.7 | 0.6 |
| SAOUHSC_01705 | Enterotoxin family protein | 0.7 | 0.9 |
| Hypothetical protein genes | |||
| SAOUHSC_00817 | Hypothetical protein | −0.8 | −0.2 |
| SAOUHSC_01295 | Hypothetical protein | −0.7 | −0.2 |
| SAOUHSC_01296 | Hypothetical protein | −0.7 | −0.3 |
| SAOUHSC_01297 | Hypothetical protein | −0.9 | −0.3 |
| SAOUHSC_01533 | Hypothetical protein | −1.2 | 0.8 |
| SAOUHSC_02141 | Hypothetical protein | −0.7 | −0.7 |
| SAOUHSC_00966 | Hypothetical protein | −0.8 | −0.2 |
| SAOUHSC_02688 | Hypothetical protein | −0.8 | −0.5 |
| SAOUHSC_00323 | Hypothetical protein | −0.7 | −0.1 |
| SAOUHSC_00830 | Hypothetical protein | −0.8 | −0.3 |
| SAOUHSC_02596 | Hypothetical protein | −0.9 | −0.6 |
| SAOUHSC_00043 | Hypothetical protein | −0.7 | −0.5 |
| SAOUHSC_01548 | Hypothetical protein | 0.9 | 1.3 |
| SAOUHSC_02933 | Hypothetical protein | 0.8 | 1.1 |
| SAOUHSC_02761 | Hypothetical protein | 0.8 | 1 |
| SAOUHSC_01921 | Hypothetical protein | 0.7 | 0.5 |
| SAOUHSC_00971 | Hypothetical protein | 0.7 | 0.8 |
| SAOUHSC_02787 | Hypothetical protein | 0.7 | 0.3 |
| SAOUHSC_02865 | Hypothetical protein | 0.7 | 0.3 |
a
PTS, phosphotransferase system.