TABLE 5.
Basic pharmacokinetic parameters of NAB741 compared to those of NAB7061 and NAB739 (1) and of colistin (13)
| Parameter | Value (mean ± SD; n = 4) |
|||
|---|---|---|---|---|
| NAB739 | NAB741 | NAB7061 | Colistin | |
| Half-life (min) | 69.0 ± 21.9 | 32.7 ± 2.41 | 66.2 ± 12.3 | 74.6 ± 13.2 |
| Volume of distribution (ml/kg) | 222 ± 20.5 | 243 ± 24.0 | 339 ± 96 | 496 ± 60 |
| Clearance (ml/min/kg) | 2.63 ± 0.54 | 7.39 ± 0.85 | 3.84 ± 0.75 | 5.22 ± 0.41 |
| Urinary recovery (% of dose) | 19.4 ± 7.38 | 50.9 ± 13.6 | 7.16 ± 3.70 | 0.18 ± 0.14 |
| Renal clearance (ml/min/kg) | 0.53 ± 0.30 | 3.78 ± 1.11 | 0.28 ± 0.16 | 0.010 ± 0.008 |