TABLE 2.
Histopathological analysis of tissuesa
| Tissue | Amastigote nests/20 fieldsb |
||
|---|---|---|---|
| Control (n = 5) | Bz (n = 5) | 7a (n = 4) | |
| Heart | 15.7 (± 4.6) | 12.3 (± 5.0) | 5.3 (± 4.6)* |
| Bladder | 54.7 (± 17.9) | 36.7 (± 5.5) | 4.7 (± 4.5)* |
| Lung | 1.3 (±1.5) | 0 | 0.3 (± 0.58) |
| Intestine | 21.5 (± 0.7) | 0.67 (± 1.2)* | 0* |
| Spleen | 4.7 (± 3.2) | 2.3 (± 3.2) | 0.67 (± 1.2) |
| Muscle | 0 | 0 | 0 |
a
The sections of hematoxylin/eosin-stained tissues from mice treated i.p. with three doses per day of 7a at 40 nmol·kg−1 body weight during 13 days after infection with 500 bloodstream trypomastigotes (Y strain) were scored for the number of parasite nests on the indicated tissues. *, P < 0.05.
b
Values are means ± standard deviations from 20 fields; magnification, ×400. Bz, benznidazole.