TABLE 1.
Antiviral activities of AH and HHA in different cell lines
| CBA | EC50a (μM) |
||||
|---|---|---|---|---|---|
| HIV-1(IIIB) | HIV-2(ROD) | SIV(mac251) | SHIV(sm239) | HuT-78/HIV-1 + Sup-T1 | |
| Actinohivin | 0.025 ± 0.005 | 0.488 ± 0.238 | >4 | 0.68 ± 0.17 | 1.2 ± 0.1 |
| HHA | 0.006 ± 0.002 | 0.004 ± 0.002 | 0.163 ± 0.024 | 0.010 ± 0.001 | 0.110 ± 0.012 |
a
For HIV-1(IIIB), HIV-2(ROD), SIV(mac251), and SHIV(sm239), EC50s are the concentrations required to inhibit virus-induced cytopathogenicity in CEM (HIV) and U87 CD4+ CCR5+ CXCR4+ (SIV) cell cultures by 50%. For HuT-78/HIV-1 + Sup-T1, the EC50 is the concentration required to inhibit syncytium formation between HuT-78/HIV-1 and Sup-T1 cells by 50%. Data are the means of at least two to four independent experiments.