FIG. 3.

Synergistic effect of cysteamine on artemisinin efficacy against replication of Plasmodium chabaudi in vivo. Groups (n = 6) of female A/J (A and B) or C57BL/6 (C) mice were infected with P. chabaudi (10⁷ pRBC, i.v.) and treated for 4 days (days 0, 1, 2, and 3) with indicated doses (in mg/kg) of artesunate (A and C) or dihydroartemisinin (DHA) (B) and/or cysteamine (170 mg/kg, i.p.), and blood parasitemia (expressed as percentage of parasitized erythrocytes) was determined at days 4 (left) and 5 (right) postinfection. In all experiments, control groups were treated with PBS. The presence or absence of cysteamine is indicated by a plus or a minus, respectively, and doses of artemisinin derivatives in mg/kg are indicated below. Each dot represents a mouse and bars indicate the mean of the group.