FIG. 6.

Effect of cysteamine and artesunate combinations on progression of P. chabaudi in pantetheinase-sufficient B6 mice. Groups (n = 6) of female B6 mice were infected with P. chabaudi (10⁶ pRBC, i.v.) and treated for 4 days (days 0, 1, 2, and 3) with either PBS or artesunate (1.0 or 30 mg/kg) combined with, or without, cysteamine (60 mg/kg) (A), all given i.p. Blood parasitemia was measured daily up to day 22 (expressed as percentage of pRBC). Solid and dashed lines represent mice receiving artesunate doses alone or in combination with cysteamine, respectively. Error bars represent standard deviation of the mean, and arrows represent drug treatment days. (B) Parasitemia levels at day 6 postinfection for all experimental groups are shown, with each dot representing a mouse. Mean levels are shown as bars.