TABLE 1.

Effect of cysteamine and artemisinin derivative combinations on blood-stage replication of Plasmodium chabaudi in vivo

Mouse type and drug	Dose (mg/kg)	Cysteamine (170 mg/kg)	Inhibition of parasitemia (% PBS control)a
			Day 4	Day 5
Pantetheinase-deficient A/J
Artesunate	0.2	−	30	20
Artesunate	0.2	+	65*	56*
Artesunate	0.5	−	65	43
Artesunate	0.5	+	93	80*
DHA	0.15	−	22	13
DHA	0.15	+	56*	46*
DHA	0.3	−	50	40
DHA	0.3	+	80	71*
NAb	0	+	28	23
Pantetheinase-sufficient C57BL/6
Artesunate	0.5	−	29	21
Artesunate	0.5	+	71*	65*
NA	0	+	13	25

^a* indicates synergy between the compounds.

^bNA, no drug administered.