TABLE 2.
Final parameter estimates for RFP
| Parameter | Estimate (RSEa [%]) | IIVb (RSE [%]) | IOVc (RSE [%]) |
|---|---|---|---|
| CL1/F (liters/h)d | 2.14 (13.6) | 19.2 (24.3) | 12.2 (9.1) |
| CL2/F (liters/h)e | 3.22 (11.9) | 19.2 (24.3) | 12.2 (9.1) |
| MTT (h) | 1.45 (10.8) | 9.5 (87.0) | 24.2 (13.4) |
| F | 1 (fixed) | 21.4 (35.3) | 29 (16.6) |
| MTIME (h)f | 43 (2.6) | ||
| V/F (liters) | 60.6 (9.2) | ||
| NN | 10.9 (9.6) | ||
| ka (h−1) | 1.66 (13.1) | ||
| Residual variability | |||
| Additive error (mg/liter) | 0.206 (12.3) | ||
| Proportional error (%) | 10.6 (1.81) |
a
RSE, relative standard error expressed as percentage of estimate.
b
IIV, interindividual variability expressed as coefficient of variation (CV).
c
IOV, interoccasional variability expressed as CV.
d
Oral clearance of RFP before MTIME.
e
Oral clearance of RFP after MTIME.
f
MTIME is the estimated time when oral clearance of RFP changes.