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. 2010 Jun 1;54(8):3390–3394. doi: 10.1128/AAC.00345-10

TABLE 3.

Different meal effects, relative to fasted state, estimated from the parent (RFP) model

Meala % increase in oral bioavailability RSEb (%)
A 85.7 20.1
B 32.7 40.4
C 45.7 29.3
D 48.9 30.7
a

Meals are as defined in Table 1. The model was parameterized for meal effects on oral bioavailability (F), first-order absorption rate constant (ka), and mean transit time (MTT). Meal effects on ka and MTT were dropped in the final model since they became insignificant.

b

RSE, relative standard error.