TABLE 4.
Final parameter estimates for 25-DRFP
| Parameter | Estimate (RSEa [%]) | IIVb (RSE [%]) | IOVc (RSE [%]) |
|---|---|---|---|
| CLM1/F (liters/h)d | 1.81 (8.7) | 23.9 (23.9) | 30.2 (10.6) |
| CLM2/F (liters/h)e | 4.63 (8.1) | 23.9 (23.9) | 30.2 (10.6) |
| MTIME (h)f | 46.8 (0.3) | ||
| VMC/F (liters)g | 6.36 (5.8) | ||
| VMP/F (liters)h | 22.1 (4.8) | ||
| QM (liters/h)i | 4.4 (6.9) | ||
| Residual variability | |||
| Additive error (mg/liter) | 0.211 (9.7) | ||
| Proportional error (%) | 19.1 (0.7) |
a
RSE, relative standard error expressed as percentage of esimate.
b
IIV, interindividual variability expressed as coefficient of variation (CV).
c
IOV, interoccasional variability expressed as CV.
d
Oral clearance of 25-DRFP before MTIME.
e
Oral clearance of 25-DRFP after MTIME.
f
MTIME is the estimated time when oral clearance of 25-DRFP changes.
g
VMC/F, apparent volume of distribution of 25-DRFP in the central compartment.
h
VMP/F, apparent volume of distribution of 25-DRFP in the peripheral compartment.
i
QM, intercompartmental clearance of 25-DRFP.