TABLE 1.
Killing of intracellular wild-type S. Typhimurium LT2 and L. monocytogenes in J774A.1 cellsa
| Group |
Salmonella |
Listeria |
||
|---|---|---|---|---|
| Log CFU (±SD) | Log CFU reduction | Log CFU (±SD) | Log CFU reduction | |
| Control | 4.06 (0.16) | 0.00 | 5.63 (0.35) | 0.00 |
| Free gentamicin | 3.98 (0.05) | 0.08 | 5.67 (0.14) | −0.04 |
| PN copolymers | 3.91 (0.08) | 0.15 | 5.50 (0.10) | 0.13 |
| PNs | 3.53 (0.20) | 0.53* | 2.46 (0.11) | 3.17* |
a
Shown are results for killing of intracellular wild-type S. Typhimurium LT2 and L. monocytogenes in J774A.1 cells incubated with free gentamicin, the copolymers alone, or the PNs at a dose of 25 μg gentamicin/ml for 6 h. Each result is the mean from triplicate assays performed together ± SD. Asterisks indicate values found to be significantly different (confidence level; t test, 0.05) from that for free gentamicin by statistical analysis (ANOVA followed by Tukey's procedure for multiple comparisons).