TABLE 1.
MICs and MFCs of 10 bis(alkylpyridinium)alkanes against 19 species of fungi
| Strain | MIC/MFC (μg/ml) of test compounda: |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
| Candida albicans ATCC 90028 | 1.48 | 1.48 | 2.96/5.9 | 1.48/2.96 | 0.79 | 3.2 | 1.74 | 1.58 | 1.86 | 1.86 |
| C. albicans ATCC 10231 | 1.48b | 1.48 | 2.96 | 1.48/5.9 | 0.79 | 3.2 | 1.74 | 1.58 | 1.86b | 1.86 |
| Candida krusei ATCC 6258 | 5.9b/11.8 | 23.7 | 23.7 | 5.9/11.8 | 3.2 | 25.3 | 13.9 | 6.3 | 1.86b | 3.7 |
| C. krusei ATCC 9258 | 5.9/11.8 | 23.7 | 11.8/23.7 | 11.8 | ND/NDc | ND/ND | ND/ND | ND/ND | 1.86/3.7 | ND/ND |
| C. krusei 04-202328 | 11.8 | 23.7 | 23.7/47.3 | 11.8 | 3.2 | 25.3 | 13.9/27.9 | 6.3 | 1.86 | 3.7 |
| Candida parapsilosis ATCC 22019 | 0.74b/1.48 | 0.74/1.48 | 1.48/2.96 | 1.48/2.96 | 0.79 | 1.58/3.2 | 0.87/1.74 | 0.79 | 1.86b | 1.86 |
| C. parapsilosis 04-202398 | 47.3 | 47.3 | >47.3 | 47.3 | 25.3/50.7 | 50.7 | 55.8/>55.8 | 25.3/50.7 | 7.5/14.9 | 14.9/29.8 |
| Candida glabrata 04-202345 | 1.48 | 0.37 | 1.48/5.9 | 1.5/3.0 | 0.79 | 0.79/1.58 | 0.87 | 0.79/3.2 | 0.93 | 1.86 |
| Candida tropicalis 04-202361 | 0.74 | 0.74 | 2.96 | 1.48/5.9 | 0.79 | 1.58 | 0.87 | 0.79/1.58 | 1.86 | 1.86 |
| Cryptococcus neoformans ATCC 90112 | 1.48b | 5.9 | 2.96 | 11.8 | 0.79 | 1.58 | 1.74 | 0.79 | 1.86b | 1.86/3.7 |
| C. neoformans 05-202523 | 47.3 | 47.3 | 11.8/47.3 | 11.8/23.7 | 6.3/25.3 | 25.3/50.7 | 27.9 | 12.7/25.3 | 7.5 | 3.7/7.5 |
| Cryptococcus gattii 05-200122 | 0.74 | 1.48 | 1.48 | 1.48 | 0.79 | 1.58 | 1.74 | 0.79 | 1.86 | 1.86 |
| Aspergillus fumigatus ATCC 204305 | 47.3b | >47.3 | >47.3 | >47.3 | 12.7/50.7 | >50.7 | 27.9 | 25.3/50.7 | 7.5b/14.9 | 14.9/29.8 |
| A. fumigatus 05-203114 | 47.3 | >47.3 | >47.3 | >47.3 | 12.7/50.7 | >50.7 | 13.9/55.8 | 25.3 | 7.5/14.9 | 14.9/59.7 |
| Aspergillus flavus ATCC 204304 | 23.7b/47.3 | >47.3 | >47.3 | >47.3 | 12.7/25.3 | >50.7 | 55.8 | 12.7/25.3 | 7.5b/14.9 | 14.9/59.7 |
| A. flavus 05-203758 | 47.3 | >47.3 | >47.3 | >47.3 | 25.3 | >50.7 | >55.8 | 25.3/50.7 | 14.9/29.8 | 59.7 |
| Aspergillus terreus 05-202844 | 5.9b/11.8 | 0.74/1.48 | 2.96/5.9 | 1.48 | 0.79 | 50.7 | 1.74 | 0.7 | 0.93b/1.86 | 3.7/14.9 |
| Scedosporium prolificans 05-203060 | 1.48b/2.96 | 1.48/5.9 | 2.96 | 1.48 | 25.3 | 1.58/12.7 | >55.8 | 1.58/6.83 | 1.86b/3.7 | 3.7 |
| Scedosporium apiospermum 05-203100 | 2.96b | 1.48 | 11.8 | 11.8 | 50.7 | 6.3/12.7 | >55.8 | 6.3 | 3.7b | 1.86 |
| Cunninghamella bertholiae 99-12187 | 47.3 | 47.3 | >47.3 | >47.3 | 12.7/25.3 | >50.7 | 27.9 | ND/ND | 7.5 | 14.9/29.8 |
| Absidia corymbifera 04-200170 | >47.3 | >47.3 | >47.3 | >47.3 | 50.7 | >50.7 | >55.8 | 50.7 | 14.9/27.8 | 29.8/59.7 |
| Exophiala jeanselmei 03-200268 | 1.48/2.96 | 0.74/2.96 | 2.96 | 5.9 | 0.79 | 1.58/3.2 | 1.74 | 1.58 | 1.86/3.7 | 3.7 |
| Exophiala spinifera 03-200803 | 0.37 | 0.37/0.74 | 1.48 | 0.74 | 1.58 | 0.79 | 1.74 | 0.79/1.58 | 1.86 | 1.86 |
| Fusarium solani 04-203102 | 47.3 | 23.7 | 47.3 | 47.3 | 12.7 | >50.7 | 27.9 | 12.7 | 14.9 | 29.8/59.7 |
| Paecilomyces lilacinus 05-200601 | >47.3 | >47.3 | >47.3 | >47.3 | 50.7 | >50.7 | >55.8 | >50.7 | 14.9/29.8 | 59.7 |
| Rhizopus oryzae 05-203111 | 1.48b/5.9 | 2.96/5.9 | 5.9/23.7 | 5.9/23.7 | 0.79 | 6.3/25.3 | 0.87/1.74 | 1.58/6.3 | 1.86b | 3.7 |
a
Minimal fungicidal concentrations (MFC) are given only where they differ from the MIC. The MFCs in many cases were the same as the MIC.
b
As previously tested in the study by Obando et al. (30).
c
ND, not done.