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. 2010 Jun 7;54(8):3233–3240. doi: 10.1128/AAC.00231-10

TABLE 2.

MICs of four bis(alkylpyridinium) compounds and five standard antifungal drugs against clinical isolates of yeasts

Species and antifungal agent or compounda MIC (μg/ml)b
 MFC (μg/ml)c
Range GM 50% 90% Range 50% 90%
Candida albicans
    AMB 0.06-0.5 0.20 0.25 0.5
    FLC 0.26-64 1.15 0.50 16
    ITC 0.02-0.18 0.07 0.04 0.09
    VRC 0.002-0.17 0.04 0.01 0.17
    POS 0.01-0.18 0.04 0.02 0.18
    CAS 0.07-0.27 0.12 0.14 0.27
    Compound 1 0.75-1.48 0.21 1.48 1.48 0.75-1.48 1.48 1.48
    Compound 4 0.75-1.47 1.28 1.47 1.47 0.75-2.94 1.47 1.47
    Compound 5 1.56 1.56 1.56 1.56 1.56-3.11 1.56 1.56
    Compound 8 0.79-1.56 1.36 1.56 1.56 0.79-1.56 1.56 1.56
Candida tropicalis
    AMB 0.06-0.5 0.22 0.25 0.5
    FLC 0.076-2.45 1.41 1 4
    ITC 0.03-0.25 0.11 0.125 0.25
    VRC 0.008-0.25 0.07 0.125 0.25
    POS 0.016-0.25 0.061 0.06 0.25
    CAS 0.06-0.25 0.14 0.125 0.25
    Compound 1 0.38-0.75 0.702 0.75 0.75 0.38-0.75 0.75 0.75
    Compound 4 0.37-1.47 0.746 0.75 1.47 0.37-1.47 0.75 1.47
    Compound 5 0.39-1.56 1.183 1.56 1.56 0.39-1.56 1.56 1.56
    Compound 8 0.39-1.56 0.790 0.79 0.79 0.39-1.56 0.79 1.56
Candida glabrata
    AMB 0.06-0.5 0.18 0.125 0.25
    FLC 16-256 32 16 256
    ITC 0.5-16 1.15 0.5 16
    VRC 0.125-4 0.41 0.25 4
    POS 0.25-8 1.23 1 8
    CAS 0.125-0.5 0.19 0.125 0.25
    Compound 1 0.38-1.48 0.701 0.75 0.75 0.38-1.48 1.48 1.48
    Compound 4 0.37-1.47 0.975 1.47 1.47 0.75-5.87 1.47 5.87
    Compound 5 0.39-0.79 0.739 0.79 0.79 0.39-1.56 1.56 1.56
    Compound 8 0.39-1.56 0.642 0.79 0.79 0.39-1.56 0.79 1.56
Candida parapsilosis
    AMB 0.03-0.5 0.28 0.25 0.5
    FLC 1-8 2.14 2 4
    ITC 0.02-0.125 0.07 0.06 0.125
    VRC 0.02-0.125 0.043 0.06 0.06
    POS 0.02-0.125 0.049 0.06 0.06
    CAS 0.125-2 0.66 0.5 1
    Compound 1 >47 >47 >47 >47 >47 >47 >47
    Compound 4 23.5 23.5 23.5 23.5 23.5 23.5 23.5
    Compound 5 24.9-49.5 28.56 24.9 49.5 24.9-49.5 49.5 49.5
    Compound 8 24.9-49.5 30.58 24.9 49.5 49.5 49.5 49.5
Candida krusei
    AMB 0.06-0.5 0.22 0.25 0.5
    FLC 64-128 84.45 64 128
    ITC 0.125-1 0.33 0.25 0.5
    VRC 0.125-1 0.41 0.25 1
    POS 0.06-0.5 0.18 0.125 0.25
    CAS 0.06-1 0.31 0.25 0.5
    Compound 1 0.38-11.8 2.253 2.96 5.91 0.38-11.8 2.96 5.91
    Compound 4 0.75-11.74 3.383 2.94 5.87 0.75-11.74 5.87 11.74
    Compound 5 0.79-3.11 1.362 1.56 1.56 0.79-3.11 1.56 3.11
    Compound 8 0.79-12.45 3.122 3.11 6.22 0.79-12.45 6.22 6.22
Candida dubliniensis
    AMB 0.016-0.25 0.10 0.125 0.125
    FLC 0.125-32 0.43 0.25 0.5
    ITC 0.008-0.06 0.028 0.03 0.06
    VRC 0.008-0.06 0.011 0.008 0.016
    POS 0.008-0.06 0.014 0.008 0.03
    CAS 0.03-0.125 0.070 0.06 0.125
    Compound 1 0.75-1.48 0.805 0.75 0.75 0.75-1.48 0.75 1.48
    Compound 4 1.47-5.87 2.224 1.47 2.93 1.47-5.87 2.93 2.93
    Compound 5 0.39-0.79 0.739 0.79 0.79 0.79-1.48 0.79 0.79
    Compound 8 0.79-3.11 0.908 0.79 0.79 0.79-3.11 0.79 1.56
Candida guilliermondii
    AMB 0.06-0.5 0.15 0.125 0.25
    FLC 1-32 7.46 4 16
    ITC 0.125-1 0.5 0.5 1
    VRC 0.03-0.25 0.124 0.125 0.25
    POS 0.03-0.25 0.14 0.125 0.25
    CAS 0.5-2 1.15 1 2
    Compound 1 0.38-1.48 0.569 0.38 0.75 0.38-1.48 0.75 0.75
    Compound 4 0.75-5.87 1.692 1.47 1.47 0.75-5.87 1.47 5.87
    Compound 5 0.39-3.11 0.789 0.79 1.56 0.39-3.11 0.79 1.56
    Compound 8 0.39-3.11 0.903 0.79 1.56 0.39-3.11 0.79 1.56
Candida lusitaniae
    AMB 0.06-0.25 0.12 0.125 0.25
    FLC 0.5-32 2.64 2 4
    ITC 0.03-0.25 0.09 0.06 0.25
    VRC 0.008-0.25 0.02 0.03 0.16
    POS 0.008-0.06 0.015 0.016 0.03
    CAS 0.125-4 0.54 0.5 1
    Compound 1 0.75-1.48 0.86 0.75 1.48 0.75-1.48 1.48 1.48
    Compound 4 1.47-5.87 2.74 2.93 2.93 1.47-5.87 2.93 5.87
    Compound 5 0.79-1.56 1.04 0.79 1.56 0.79-12.44 0.79 6.22
    Compound 8 1.56-6.22 2.71 3.11 3.11 1.56-12.44 3.11 6.22
Cryptococcus neoformans
    AMB 0.06-0.5 0.19 0.25 0.5
    FLC 1-32 4.59 4 16
    ITC 0.03-0.125 0.06 0.06 0.125
    VRC 0.008-0.125 0.04 0.03 0.125
    POS 0.03-0.25 0.07 0.06 0.125
    CAS 8 8 8 8
    Compound 1 0.75-23.66 2.41 1.48 5.91 1.48-47.05 1.48 47
    Compound 4 1.47-11.74 3.83 2.94 5.87 2.94-11.74 5.87 11.74
    Compound 5 0.79-6.22 1.19 0.79 3.11 0.79-12.45 0.79 12.45
    Compound 8 0.79-6.22 1.28 0.79 3.11 0.79-12.45 0.79 12.45
Cryptococcus gattii
    AMB 0.06-0.5 0.19 0.25 0.25
    FLC 2-8 4 4 8
    ITC 0.03-0.125 0.07 0.06 0.125
    VRC 0.03-0.06 0.05 0.06 0.06
    POS 0.03-0.125 0.04 0.03 0.06
    CAS 8 8 8 8
    Compound 1 0.75-1.48 1.06 0.75 1.48 0.75-1.48 1.48 1.48
    Compound 4 1.47-2.94 1.81 1.48 2.94 2.94 2.94 2.94
    Compound 5 0.79 0.79 0.79 0.79 0.79-1.56 0.79 0.79
    Compound 8 0.79 0.79 0.79 0.79 0.79 0.79 0.79
a

There were 10 isolates tested for each species.

b

50% and 90%, concentrations at which 50% and 90% of the isolates, respectively, were inhibited.

c

50% and 90%, concentrations at which 50% and 90% of the isolates, respectively, were killed.