TABLE 2.
Mutations found in the 50S ribosomal proteins L4 and L22 and corresponding MICs
| S. enterica serovar | Origin | Yr | Mutation in L4 and L22 |
MICa |
|||||
|---|---|---|---|---|---|---|---|---|---|
| rlpD | rlpV | AZM | ERY | TEL | CIP | NAL | |||
| Blockley | Egypt | 2005 | G235A | 64 | >128 | >128 | 0.5 | >512 | |
| Blockley | Finland | 2005 | G235A | 64 | >128 | >128 | 0.25 | >512 | |
| Blockley | Finland | 2006 | G235A | 128 | >128 | >128 | 0.25 | >512 | |
| Saintpaul | Finland | 2006 | G235A | 64 | >128 | >128 | 0.03 | 16 | |
| Typhimurium | Thailand | 2008 | G235A | 128 | >128 | >128 | 0.06 | 16 | |
| Typhimurium | Finland | 2004 | G235A | 128 | 64 | NDb | 0.25 | 512 | |
| Montevideo | Thailand | 2004 | C379T | G25A | 4 | 64 | 32 | 0.5 | 32 |
| Montevideo | Thailand | 2007 | C379T | G25A | 8 | >128 | 32 | 0.5 | 16 |
| Montevideo | Thailand | 2008 | C379T | G25A | 8 | >128 | 4 | 0.5 | 16 |
a
AZM, azithromycin; ERY, erythromycin; TEL, telithromycin; CIP, ciprofloxacin; NAL, nalidixic acid.
b
ND, not determined.