FIG. 2.
Effect of ciprofloxacin concentration on the diversity of ciprofloxacin-resistant R. equi mutations. Each section shows the resistance mutation alleles recovered from agar plates supplemented with the indicated concentration of ciprofloxacin (μg/ml). Vertical bars indicate the number of mutants analyzed; black bars represent mutants derived from R. equi W5234, and gray bars represent mutants derived from R. equi ATCC 6939T. All amino acid substitutions were in GyrA except N464Da, derived from an amino acid substitution in GyrB.