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In vivo efficacy of NITD203. AG129 mice were intraperitoneally inoculated with 2 × 106 PFU of DENV-2 (strain TSV01) on day 0. The infected mice (6 or 8 animals per group) were immediately treated with the indicated doses of NITD203 orally twice per day for three consecutive days. The peak viremia on day 4 postinfection was quantified by a plaque assay. For comparison, the infected mice were treated with 25 mg/kg of NITD008, and the reduction of peak viremia is presented.
