FIG. 1.
Allele frequencies for dhfr (positions 51, 59, 108, and 164) and dhps (positions 437, 540, and 581) genes in the eastern Amazonas and Orinoco basins and Northwest and Southwest Pacific, Colombia. dhfr resistant alleles: wild type (NCSI), single mutant (NCNI), double mutant (ICNI), and triple mutant (ICNL). dhps resistant alleles: wild type (AKA), single mutant (GKA), double mutant (GKG), and triple mutant (GEG). (A) dhfr allele frequencies. (B) dhps allele frequencies.(Left) Allele frequencies between 1999 and 2005. (Right) Allele frequencies between 2006 and 2007.