TABLE 1.

IC₅₀s of quinine and pfnhe polymorphisms in P. falciparum

Isolate	IC50 (nM)	Codon polymorphisms			Microsatellite polymorphisms
		894	950	1437	No. of SDNN repeats	msR1	ms3580	ms4760
3D7	27.1	AAT	GTG	TAT	4	Absent	NIH	ms4760-2
AK127	569.5	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK182	549.2	AAT	GGG	TTT	2	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK227	495.3	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-1
CDA-1553	333.3	AAT	GGG	TTT	4	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK150 D-0	296.6	AAT	GGG	TAT	3	Absent	NIH	ms4760-1
AK249	270.4	AAT	GTG	TAT	3	Absent	NIH	ms4760-1
AK121	270.2	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-21
AK158	234.0	AAT	GGG	TAT	2	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK167	227.0	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK222	210.5	AAT	GGG	TAT	2	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK152 D-56	207.7	AAA	GTG	TAT	2	Absent	NIH	ms4760-6
AK062	181.5	AAT	GTG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-1
AK144	145.8	AAT	GTG	TTT	4	Absent	NIH	ms4760-23
AK018	141.1	AAT	GGG	TTT	2	Absent	NIH	ms4760-20
AK150 D-42	91.6	AAT	GGG	TAT	2	Absent	NIH	ms4760-1
9067	80.1	AAT	GTG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-3
8885	78.2	AAT	GGG	TAT	3	Absent	NIH	ms4760-22
AK183	73.9	AAT	GGG	TTT	4	TCDNNMPNNNMSNNN	Absent	ms4760-20
6816	73.3	AAT	GGG	TAT	1	TCDNNMPNNNMSNNN	NIH	ms4760-18
8966	55.8	AAT	GTG	TAT	4	TCDNNMPNNNMSNNN	Absent	ms4760-1
AK033 D-49	54.1	AAT	GGG	TAT	3	TCDNNMPNNNMSNNN	NIH	ms4760-7
AK022D-0	42.4	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-22
9070	41.5	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-22
8977	35.9	AAT	GGG	TTT	3	Absent	NIH	ms4760-7
AK033 D-0	32.8	AAT	GGG	TAT	4	Absent	NIH	ms4760-1
8968	30.6	AAA	GGG	TAT	4	Absent	NIH	ms4760-2
8948	27.8	AAA	GGG	TAT	4	Absent	NIH	ms4760-7
AK022 D-28	22.0	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-1
8973	20.0	AAT	GGG	TAT	4	TCDNNMPNNNMSNNN	NIH	ms4760-7