TABLE 4.

Correlates of DAP^r among recent S. aureus isolates: comparison with current DAP^s and DAP^r primary strain set

DAPr strain(s)	Source	Increased positive surface charge	Potential mechanism(s) of increased positive surface	Genetic factor(s) potentially involved in surface charge alterations	CW thickness	Reference
CB2205 (MRSA MW2 USA 400)	In vitro selection by serial passage in DAP	No	NAa	NA	↑b	16
701, 703 (MSSAc)	Clinical isolates - endocarditis	Yes	Increased LPG translocation to outer membrane leaflet	Increased mprF transcription (stationary phase), S295L point mutation	↑	11, 37
BOY300 (MSSA)	Clinical isolate - endocarditis	Yes	Increased teichoic acid alanylation	Increased dlt transcription	↑	36
MRSA 11/21, REF2145 (MRSA USA 300)	Clinical isolates - endocarditis	Yes	Increased total LPG synthesis	Increased mprF transcription (exponential phase), T345A point mutation	Equivalent	This study

^aNA, not applicable.

^b↑, increased.

^cMSSA, methicillin-susceptible S. aureus.