TABLE 3.
Comparison of 3TC-derived pharmacokinetic parameters between our study and the latest publications of data from HIV-1-infected children
| Study (reference) | Group | Dose | Value for parametera: |
|||
|---|---|---|---|---|---|---|
| Cmin (mg/liter) | Cmax (mg/liter) | AUC0→τ (mg/liter·h) | CL/F (liters/h/kg) | |||
| l'Homme et al. (14) | Mean age, 6.9 yr (n = 65) | 4 mg/kg q12h | 0.09 | 1.33 [0.69] | 5.42 [2.26] | |
| Burger et al. (5) | Median age, 3.8 yr (IQR, 2.5-4.8 yr) (n = 17) | 4 mg/kg q12h | 0.07 (0.06-0.08) | 0.98 (0.82-1.43) | 3.71 (3.44-6.17) | 1.03 (0.67-1.22) |
| Burger et al. (5) | Median age, 10.1 yr (IQR 8.5-12.3 yr) (n = 34) | 4 mg/kg q12h | 0.09 (0.07-0.11) | 1.84 (1.21-2.28) | 6.54 (5.21-8.58) | 0.57 (0.45-0.74) |
| Bergshoeff et al. (4) | Age, 2.1-12.8 yr (n = 19) | 4 mg/kg q12h | 0.067 | 1.11 (0.96-1.29) | 4.44 (3.83-5.14) | 0.90 (0.78-1.04) |
| Bergshoeff et al. (4) | Age, 2.1-12.8 yr (n = 19) | 8 mg/kg q24h | 0.05 | 2.09 (1.80-2.42) | 9.80 (8.64-11.12) | 0.80 (0.70-0.92) |
| This study | Age, 2.5-14 yr (n = 45) | 8 mg/kg q24h | 0.04 (0.01-0.14) | 1.7 (1.34-2.01) | 7.8 (4.72-14.27) | 1.03 (0.55-1.62) |
a
Values for the study by l'Homme et al. (14) are given as means [standard deviation]. All other values are median values, with interquartile ranges (IQR) shown in parentheses.