TABLE 4.
Population PK parameter valuesa of the final model
| Statistic | Random parameters |
Fixed parameters |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CL23 | CL24 | CL34 | V2 | V3 | V4 | CL10 | K12 | K21 | V1 | |
| Mean | 0.279 | 0.00967 | 0.362 | 5.407 | 1.607 | 12.024 | 1.309 | 3.068 | 6.795 | 17.617 |
| Median | 0.0903 | 0.0118 | 0.0143 | 3.519 | 0.851 | 15.361 | ||||
| SD | 0.772 | 0.0236 | 0.708 | 4.992 | 1.455 | 5.712 | ||||
a
Subscript numeral correspond to compartments as follows: 1, central (plasma) compartment; 2, peripheral compartment; 3, AC compartment; 4, ELF compartment. K12 and K21 (in h−1) are transfer rate constants between the central and the peripheral compartments. CL10 (in liters/h) is the elimination clearance from the central compartment; CL23, CL24, CL34 (in liters/h) are the intercompartmental clearances. V1, V2, V3, and V4 (in liters) are the volumes of distribution in the indicated compartment.