TABLE 6.
Drug exposures predicted in lung transplant patients receiving micafungin administered intravenously once daily for 14 days
| Plasma | ACs | ELF | |
|---|---|---|---|
| Day 1 | |||
| AUC0-24h (mg.h.L−1) | 79.2 ± 4.4* | 208.1 ± 275.6 | 14.4 ± 18.4 |
| AUC ratios** | NA | 2.65 ± 3.51 | 0.18 ± 0.23 |
| Day 7 | |||
| AUC0-24h (mg.h.L−1) | 117.4 ± 31.4 | 387.7 ± 437.6 | 137.6 ± 154.1 |
| AUC ratios | NA | 3.59 ± 4.08 | 1.28 ± 1.41 |
| Day 14 | |||
| AUC0-24h (mg.h.L−1) | 118.1 ± 33.6 | 409.9 ± 467.2 | 214.4 ± 240.2 |
| AUC ratios | NA | 3.80 ± 4.36 | 1.98 ± 2.16 |
| Day 1 to 14 | |||
| AUC0-14d (mg.h.L−1) | 1584.6 ± 376.9 | 5190.6 ± 5958.7 | 1864.6 ± 2070.8 |
| AUC ratios | NA | 3.53 ± 4.07 | 1.27 ± 1.38 |
*All data are given as mean ± SD.
**AUC ratio = AC AUC0-24h/Plasma AUC0-24h and ELF AUC0-24h/ Plasma AUC0-24h.