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NO-dependent downregulation of PGC-1α expression requires inactivation of Foxo3a by Akt. Foxo3a is a direct and positive regulator of PGC-1α expression, and its inactivation leads to the transcriptional downregulation of PGC-1α. Foxo3a inactivation and PGC-1α downregulation result in reduced ROS detoxification capacity, increased levels of ROS, and induction of endothelial migration.
