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ClustalW alignments of ComS (A) and MecA (B) colored with JalView. The same colors in all rows mark conserved amino acids. (A) Black boxes show ComS amino acids essential for the competence development (40, 43). (B) The domain structure of MecA is highlighted. The roman numeral I corresponds to the ComK and ComS binding domain, II indicates a predicted loop region, and III indicates the ClpC binding domain (41). The black box marks a second ComS binding domain (43).
