TABLE 1.

In vitro activity of several antimicrobial agents against ESBLEC

Agent	MIC (μg/ml)			%Sa
	Range	MIC50	MIC90
Cefotaxime	8->128	>128	>128	0
Ceftazidime	≤0.5->128	64	>128	0
Cefepime	≤1->32	>32	>32	0
Cefoxitin	≤2->32	4	16	88.2
Cefotetan	≤1-4	<1	<1	100
Amoxicillin-clavulanate (2:1)	≤0.25-128	8	32	69.3
Piperacillin-tazobactam (4 μg/ml)	≤0.5->64	4	32	88.6
Imipenem	≤0.5-1	<0.5	<0.5	100
Meropenem	≤0.5	≤0.5	≤0.5	100
Ertapenem	≤0.007-2	0.03	0.125	100
Amikacin	0.125-128	2	16	98
Gentamicin	≤0.06->128	0.5	64	78.3
Tobramycin	0.125-128	1	32	76
Ciprofloxacin	≤0.06->128	16	128	29.1
Cotrimoxazole	0.05/0.013->512/27	>512/27	>512/27	36.1
Tigecycline	0.06-2	0.125	0.25	100
Nitrofurantoin	2->512	16	64	87

^a%S, the percent susceptibility determined according to CLSI guidelines (4).