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. 2010 Jul 12;49(31):6576–6586. doi: 10.1021/bi1009387

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Copyright © 2010 American Chemical Society

This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org.

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PPIase activity is necessary for CYP33-mediated repression. (A) The expression of MLL target genes was monitored by Q-RT-PCR after transfection of HEK293T cells with an empty vector, wild-type CYP33, and the CYP33-PPIase mutant. (B) Expression levels of the wild-type and PPIase mutant of CYP33 normalized to β2M. (C) Scheme for the chymotrypsin-coupled proline isomerase assay (45). (D) Comparison of the cis/trans conversion rates for four prolines in histone tails with (red) or without (blue) CYP33.