Table 4.
Incidence of Adverse Events by Severity (N = 100)
| No. of Patients (%) | |||
|---|---|---|---|
| AE | All Grades | Grade 3 | Grade 4 |
| Hematologic AEs* | |||
| Anemia | 94 (94) | 7 (7) | 3 (3) |
| Thrombocytopenia | 88 (88) | 19 (19) | 6 (6) |
| Neutropenia | 83 (83) | 38 (38) | 23 (23) |
| Febrile neutropenia | 6 (6) | 5 (5) | 1 (1) |
| Nonhematologic AEs† | |||
| Nausea | 77 (77) | 4 (4) | 0 |
| Infection | 69 (69) | 15 (15) | 6 (6) |
| Fatigue | 64 (64) | 12 (12) | 2 (2) |
| Diarrhea | 42 (42) | 5 (5) | 0 |
| Vomiting | 40 (40) | 2 (2) | 0 |
| Fever | 36 (36) | 1 (1) | 0 |
| Constipation | 31 (31) | 0 | 0 |
| Anorexia | 24 (24) | 3 (3) | 0 |
| Headache | 21 (21) | 0 | 0 |
| Stomatitis | 21 (21) | 0 | 0 |
| Infusion reaction | 14 (14) | 1 (1) | 1 (1) |
AE indicates adverse event.
*
Severity was determined using National Cancer Institute Common Toxicity Criteria (version 3.0.19).
†
Listed are common nonhematologic AEs that occurred in >20% of patients and all grade 3/4 nonhematologic AEs that occurred in >1 patient.