Table 1.

Algorithm improvements

Algorithma	TPb	FPc	TNd	FNe
Original	46	1823	12 367	2
Updated abundance values	46	895	13 295	2
Core/interfacial-specific (CISA) β-strand prediction	46	1772	12 418	2
Modified β-Barrel Score	46	625	13 565	2
All modifications combined (Freeman-Wimley algorithm)	46	599	13 591	2
Freeman-Wimley algorithm with MRS Screen	37	161	14 029	11

^aDescribes which version of the algorithm was used to make predictions in the NRPDB (Non-redundant PDB).

^bTrue Positive predictions (correctly identified TMBBs).

^cFalse Positive predictions (incorrectly identified non-TMBBs).

^dTrue Negative predictions (correctly excluded non-TMBBs).

^eFalse Negative predictions (incorrectly excluded TMBBs).