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. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3320–3329. doi: 10.1021/jm100047k

Figure 4. Subcellular Distribution and Downregulation of ERα Protein by ICI and compounds 36, 25, 4, 42, 17 (Panel A) and 33, 34, 24, 15, and 26 (Panel B).

Figure 4

MCF-7 cells were treated with 1 μM compounds for 16h, and the level of cellular ERα in the indicated subcellular fraction and in whole cell extracts was measured by Western immunoblotting. Sp1 was monitored as an internal reference for gel loading.