Skip to main content
. Author manuscript; available in PMC: 2011 Apr 22.
Published in final edited form as: J Med Chem. 2010 Apr 22;53(8):3320–3329. doi: 10.1021/jm100047k

Figure 6. Impact of Different Compounds on ERα Mediated Transcriptional Activity.

Figure 6

MCF-7 cells were treated with 1 μM compounds for 16h and then with vehicle (0.1% ethanol) or 1 nM estradiol for 4h. Real-time PCR analysis was performed for E2-stimulated ERα-target genes (Panel A) or E2-repressed ERα-target genes (Panel B), as a measure of compound ability to antagonize estradiol action.