Table 1. Drug susceptibility of M. smegmatis 16S rRNA mutants: wild-type S12 versus K42R.

16S rRNA residues		S12	MIC (µg/mL)					Reference
1408	1409–1491		Pm	Nm	Gm	Tb	Km
A	C≡G	wt	1	0.5	1	1	0.5–1	this study
A	C≡G	K42R	1	1	1	1	0.5–1	[13]
G	C≡G	wt	64	>1024	>1024	>1024	>1024	this study
G	C≡G	K42R	64	≥1024	>1024	>1024	>1024	[12]
A	C · C	wt	512	16	16–32	16	16–32	this study
A	C · C	K42R	512	16–32	16–32	16–32	16–32	[12]
A	C · U	wt	512–1024	8–16	32–64	64	64–128	this study
A	C · U	K42R	512	8–16	32	32–64	128	[12]
A	C · A	wt	32–64	2	2	2	1–2	this study
A	C · A	K42R	32	4	2	4	2	[12]
A	U · G	wt	4–8	0.5–1	8	8–16	8–16	this study
A	U · G	K42R	4–8	1	8–16	8–16	16	[12]
A	G · G	wt	32–64	4–8	1–2	8–16	32–64	this study
A	G · G	K42R	16–32	4	2–4	8–16	16–32	[12]

Pm, paromomycin; Nm, neomycin; Gm, gentamicin; Tb, tobramycin; Km, kanamycin A.