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. 2010 Aug 5;6(8):e1000873. doi: 10.1371/journal.pcbi.1000873

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Tsuda, Kawata.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) An example of the changes of the mean fitness in a population during evolution. Red line indicates the mean fitness of a population at certain generation. Horizontal dotted line indicates the time-averaged fitness (F′) during the evolution in this population. (B) The time-averaged fitness of GRNs that evolved under various fluctuations of phenotypic selection. (C) The relationship between the time-averaged fitness and the structure of GRNs. Red line indicates the fitting curve to the quintic equation by non-linear least square method.