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. 2010 Aug 5;6(8):e1001046. doi: 10.1371/journal.pgen.1001046

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Boumil et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) DNM1 isoform localization in COS-7 cells over-expressing DNM1 isoform constructs. Left is wildtype, middle is DNM1a^Ftfl and right is DNM1b. Note the tubulation in the mutant expressing cells. (B) Transferrin endocytosis and localization in COS-7 cells overexpressing DNM1 isoform constructs. Left panels show DNM1 GFP fluorescence in COS-7 cells containing wildtype or DNM1a^Ftfl; right panels show TRITC-transferrin uptake and localization in COS-7 cells containing wildtype or DNM1a^Ftfl -GFP. The arrowheads in the top right picture indicate the normal perinuclear accumulation of transferrin. The arrows in the bottom right picture indicate one point of co-localization between DNM1a^Ftfl and transferrin. (C) Quantification of transferrin localization in COS-7 cells overexpressing DNM1 isoform constructs. Transfected cells were determined to have transferrin localized to the region adjacent to the nucleus in a manner similar to non-transfected cells or to have not taken up transferrin at all or to have an abnormal localization of transferrin.