Table 1. List of genes for which RNAi induced gcs-1 expression in the intestine.
| Functional group | Gene ID | Function (NCBI-KOGs description) |
| Glutathione regeneration | C46F11.2 | mitochondrial glutathione reductase |
| Glutathione synthesis | E01A2.1 | Glutamate-cysteine ligase regulatory subunit |
| Pentose phosphate pathway | B0035.5 | gspd-1, Glucose-6-phosphate 1-dehydrogenase |
| Pentose phosphate pathway | F01G10.1 | tkt-1,Transketolase |
| Pentose phosphate pathway | Y57G11C.3 | 6-phosphogluconolactonase - like protein |
| Fatty acid oxidation | F09F7.4 | Enoyl-CoA hydratase |
| Fatty acid oxidation | T05G5.6 | ech-6, Enoyl-CoA hydratase |
| Translation | F54H12.6 | Elongation factor 1 beta/delta chain |
| Translation | T27F7.3b | eif-1, Translation initiation factor 1 (eIF-1/SUI1) |
| Translation | C36E8.1 | RNA polymerase I transcription factor |
| Translation | C48B6.2 | U3 small nucleolar ribonucleoprotein (snoRNP) component |
| Translation | Y47 D3A.16 | rsks-1, Ribosomal protein S6 kinase |
| Protein folding & degradation | T21B10.7 | cct-2, Chaperonin complex component |
| Protein folding & degradation | C17G10.2 | Hsp90 co-chaperone CNS1 (contains TPR repeats) |
| Protein folding & degradation | T06D8.8 | rpn-9, 26S proteasome regulatory complex |
| Protein folding & degradation | D1054.3 | Suppressor of G2 allele of skp1 |
| COP9 signalosome | Y59A8A.1 | csn-1 |
| COP9 signalosome | B0025.2 | csn-2 |
| COP9 signalosome | Y38C1AA.2 | csn-3 |
| COP9 signalosome | Y55F3AM.15 | csn-4 |
| COP9 signalosome | B0547.1 | csn-5 |
| COP9 signalosome | Y67H2A.6 | csn-6 |
| COP9 signalosome | K08F11.3 | cif-1, COP9 Signalosome and eIF3 complex shared subunit |
| DNA repair & degradation | Y116A8C.34 | cyn-13, Cyclophilin-type peptidyl-prolyl cis-trans isomerase |
| DNA repair & degradation | Y47G6A.8 | crn-1, 5′-3′ exonuclease |
| DNA repair & degradation | Y71H10B.1 | IMP-GMP specific 5′-nucleotidase |
| Other genes | C10E2.6 | Monocarboxylate transporter |
| Other genes | K10C2.4 | phi-43, Fumarylacetoacetase |
| Other genes | F54D8.3 | alh-1, Aldehyde dehydrogenase |
| Other genes | R07E5.10 | pdcd-2, mammalian Programmed Cell Death Protein homolog |
| Other genes | D2030.9 | wdr-23, WD40 repeat-containing protein |
| Other genes | F30A10.9 | Predicted nucleic-acid-binding protein, contains PIN domain |
| Other genes | C08B11.2 | hda-2, Histone Deacetylase |
| Other genes | F30B5.4 | Similar to oxidative stress-induced growth inhibitor 2 in H. sapiens |
| Other genes | M01B12.5 | riok-1, Similar to serine/threonine kinase RIO1. |
| Unknown function | Y41C4A.9 | Uncharacterized conserved protein |
| Unknown function | Y42G9A.1 | Unknown function |
| Unknown function | F20H11.6 | Unknown function |
| Unknown function | M01E5.4 | Unknown function |
| Unknown function | Y87G2A.1 | Unknown function |
| Unknown function | Y57E12AL.6 | Unknown function |
The RNAi screen identified 37 of these genes, and four were identified subsequently by virtue of their being COP9 signalosome subunits (csn-2, csn-3, csn-6, cif-1; see text).